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https://pubmed.ncbi.nlm.nih.gov/38093501
This study aimed to develop KASP-based SNP (Kompetitive Allele-Specific Polymerase Chain Reaction-Single Nucleotide Polymorphism) markers for routine breeding activities in yam (Dioscorea spp.). An ultra-low-density SNP marker set was created using 173,675 SNPs obtained from whole-genome resequencing of 333 diverse white Guinea yam genotypes. Of the 99 putative SNP markers found and converted to high-throughput KASP genotyping assays, 50 were highly polymorphic across six yam species and could distinguish different yam species and pedigree origins. The SNP markers also identified potential duplicates within yam species, predicted the male parent of progenies in polycrosses, and provided species identification, parental fingerprinting, and quality control in yam breeding programs.
https://pubmed.ncbi.nlm.nih.gov/38093500
This study analyzed initiatives in Australian and New Zealand dietetics curricula to determine how resilience is taught to student dietitians. The study found that 56 courses mentioned resilience factors, and academics from 14 universities were interviewed. Three themes emerged: resilience is valuable content, can be taught indirectly, and is not static. Resilience education is mainly taught by academic dietitians before placements and assessed through self-reflection. While dietetics programs include some resilience curricula, academics recognize the need to strengthen resilience content and their own knowledge base. The findings provide direction for program improvements and further research.
https://pubmed.ncbi.nlm.nih.gov/38093499
This study is a randomized controlled trial involving 380 early diabetic patients with arteriosclerotic wounds in the lower limbs. The treatment group received standard wound care plus electroacupuncture (EA), while the control group received standard wound care alone. The results showed that the treatment group had a significantly greater reduction in wound size, reduced pain scores, and higher quality of life (QoL) scores compared to the control group (p < 0.05). However, there was no significant difference in recovery time between the two groups (p > 0.05). The study suggests that EA may be an effective adjunctive treatment for early diabetic patients with lower limb arteriosclerotic lesions, promoting pain relief and quality of life. Further investigation is needed to validate these results and understand the underlying mechanisms of action.
https://pubmed.ncbi.nlm.nih.gov/38093498
The study is a survey of 235 Korean dermatologists regarding their use of polynucleotide (PN) injectables, a type of skin booster. The survey found that 88% of dermatologists use PN, with the top indications being fine lines on the cheeks, infraorbital fine lines, periorbital fine lines, uneven skin texture, dry skin, and fine lines on the forehead. Most dermatologists use a 33G needle and serial puncture technique to inject PN into the dermis, and typically recommend three sessions spaced 4 weeks apart. Additionally, 79% of PN users combine PN injection with lasers and light therapy, with radiofrequency and high-intensity focused ultrasound being the most popular. The study concludes that PN is widely used by Korean dermatologists for rejuvenation and may help them better understand and utilize PN injection.
https://pubmed.ncbi.nlm.nih.gov/38093497
This review focuses on the potential of new targets for immunotherapy in treating small cell lung cancer (SCLC), a highly aggressive malignancy with limited treatment options. Current first-line treatment with carboplatin or cisplatin plus etoposide chemotherapy offers only a 10-month survival rate, and most patients relapse within a few months. While immunotherapy has shown progress in treating SCLC patients, the benefits have been limited, with current immune checkpoint inhibitors PD-1/PD-L1 and CTLA-4 providing minimal survival improvements. The review explores four new targets (DLL3, TIGIT, LAG-3, and GD2) that could play a role in SCLC immunotherapy, aiming to find strategies to improve outcomes for SCLC patients.
https://pubmed.ncbi.nlm.nih.gov/38093496
This study investigates the relationship between thyroid function and sex hormones in female German Shepherd dogs. The researchers hypothesized that estrous stage may affect thyroid function. They monitored 17 dogs throughout their estrous cycle and analyzed blood samples for thyroid hormones (TT4, fT4, TT3, fT3, cTSH), progesterone, 17-β-estradiol, triglycerides, and cholesterol. Hematological and biochemical evaluations were also performed. Results showed that TT4, fT4, and fT3 concentrations were negatively correlated with age, and TT4 concentrations were higher in estrus and diestrus stages, positively correlated with progesterone, and negatively correlated with 17-β-estradiol. Free thyroxine did not show significant variations but was positively correlated with progesterone. Canine TSH concentrations were positively correlated with 17-β-estradiol. No significant differences in thyroid hormones and cTSH concentrations were observed between diestrus during pregnancy and pseudopregnancy. The study concludes that different stages of estrus can influence the measurement of TT4 in female dogs.
https://pubmed.ncbi.nlm.nih.gov/38093495
This study conducted a national cross-sectional survey in France to assess the opinions of nursing home nurses regarding the potential evolution of their role in antibiotic stewardship. The results showed that a majority of nurses supported expanding their antibiotic stewardship role and were open to new responsibilities, such as collecting urine samples, prescribing laboratory tests, and changing the administration route of antibiotics prescribed by general practitioners. However, fewer nurses from public nursing homes with hospital connections and with less experience were willing to prescribe antibiotics. The study concludes that further exploration is needed before implementing these new roles in antibiotic stewardship. The study adhered to relevant EQUATOR guidelines and followed the STROBE reporting guidelines.
https://pubmed.ncbi.nlm.nih.gov/38093494
The ‘Peptide for Life’ (P4L) initiative, led by the Heart Failure Association, aimed to increase the use of natriuretic peptide (NP) testing in Emergency Departments (EDs) across Western Balkan countries for the early diagnosis of heart failure. A registry of 10 centers in five countries was conducted, comparing NP adoption before and after implementing the P4L-ED study. An educational campaign and point-of-care instruments were provided to participating centers. The results showed a significant increase in NP testing in the ED from 55.9% to 80.3% before and after the P4L-ED study, respectively. Additionally, the combined use of NPs and echocardiography, as well as prescriptions for diuretics and SGLT2 inhibitors, also increased during the post-P4L-ED phase. The study suggests that increasing awareness and providing resources can improve the utilization of NPs, leading to better diagnostic accuracy and enhanced patient care.
https://pubmed.ncbi.nlm.nih.gov/38093493
This study tracks the strength development of the quadriceps and hamstrings in the uninjured limb of male professional and recreational athletes during rehabilitation after ACL reconstruction. The research shows that muscle strength in the uninjured limb increases over time, surpassing pre-surgery levels by the 3-month mark for quadriceps and the 4.5-month mark for hamstrings. This indicates that the uninjured limb should be consistently monitored during rehabilitation, as its strength may continue to change throughout the recovery process (Beware of the ‘moving target’ – uninvolved limb strength increases to exceed pre-operative values during rehabilitation after ACL reconstruction in male professional and recreational athletes, Barbosa O, Kotsifaki R, Whiteley R, King E, Korakakis V, J Orthop Sports Phys Ther. 2023 Dec 13:1-30. doi: 10.2519/jospt.2023.11961).