AI generated summary of Pubmed citation/abstract with PMID 38093490

https://pubmed.ncbi.nlm.nih.gov/38093490
The study aimed to identify host and microbial characteristics associated with recurrent prosthetic joint infections (PJIs) in patients who underwent two-stage revision arthroplasty. The researchers compared 39 cases of recurrent-PJI, who required at least two antibiotic spacers, with 67 controls of single-PJI, who received only one antibiotic spacer. The findings suggest that McPherson host grade, polymicrobial infection, and S. aureus infection are key indicators of secondary or persistent joint infection. However, bacterial resistance did not predict infection-related arthroplasty failure. Recurrent-PJI patients had higher odds of polymicrobial infections and systemic compromise, and were more likely to harbor S. aureus. Among recurrent-PJI patients, erythromycin-resistant infections were more prevalent at the final than initial spacer, despite no erythromycin exposure.