“Antimicrobial Peptide LL-37 Loses Antibacterial Activity due to DNA-LL-37 Complex Formation in the Oral Cavity: Implications for Dental Plaque and Innate Immune Responses”

https://pubmed.ncbi.nlm.nih.gov/38093556

This study finds that the antimicrobial peptide LL-37 in the oral cavity forms DNA-LL-37 complexes when binding to oral bacterial DNA, losing its antibacterial activity and potentially contributing to dental plaque formation and periodontal innate immune responses.