“PCSK9: A Promising Target for Reducing Age-Related Cardiovascular Dysfunction?” <-- note that I put a question mark at the end since I can't assume it's definitely a promising target without reading the full text.

https://pubmed.ncbi.nlm.nih.gov/38094682

PCSK9, which regulates cholesterol metabolism, may be a promising target to reduce age-related cardiovascular dysfunction, as its levels positively correlate with increasing age and cardiovascular impairment in humans and rats.