“Investigating Procaine Oiling-Out Behavior in Solvent Systems and the Potential of Modeling and Experimental Approaches for Managing Crystallization Risks”

https://pubmed.ncbi.nlm.nih.gov/38095117

This study investigates the complex oiling-out behavior of procaine in various solvent systems, identifying multiple phase regions and highlighting the potential of combining modeling and experimental approaches to manage oiling-out risks during crystallization of active pharmaceutical ingredients.