Mammalian autophagosomes originate from “autophago-domes” before DNM2-dependent scission releases them as free autophagosomes from recycling endosomes.

https://pubmed.ncbi.nlm.nih.gov/38095212

Mammalian autophagosomes originate from finger-like protrusions of recycling endosomes, referred to as “autophago-domes,” before being released as free autophagosomes through DNM2-dependent scission.