“Decreased Soluble RAGE and Increased AGEs and AOPPs in Blood of Early-Stage ALS Patients: Preliminary Study Findings”

https://pubmed.ncbi.nlm.nih.gov/38112253

This preliminary study found that in early-stage amyotrophic lateral sclerosis (ALS), there is a decrease in soluble RAGE (sRAGE) levels and an increase in advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) levels in the blood, suggesting a loss of neuroprotection and a rise in oxidative stress and protein damage.