“Citrobacter freundii Enrichment in Relapsed Multiple Myeloma Contributes to Drug Resistance and Can Be Inhibited by Furosemide Sodium”

https://pubmed.ncbi.nlm.nih.gov/38113887

The study identifies the enrichment of Citrobacter freundii in relapsed multiple myeloma patients, which contributes to drug resistance by increasing ammonium levels in MM cells, and suggests that furosemide sodium can improve progression-free survival by inhibiting ammonium uptake.