“Determining the 3D Structure of a Rare HIV-1 TAR RNA Conformational State through Mutagenesis, NMR Spectroscopy, and Computational Modeling”

https://pubmed.ncbi.nlm.nih.gov/38114465

The study used mutagenesis, NMR spectroscopy, and computational modeling to determine the 3D structure of a transient and lowly-populated conformational state in HIV-1 TAR RNA, revealing a more ordered state that cannot activate HIV-1 transcription, providing insights for RNA biology and therapeutics development.