“Germline-Somatic Mutation Interactions in Breast Cancer in a Large Chinese Cohort: Two-Hit DNA Repair Gene Inactivation Linked to Increased Genome Instability and Clinical Benefits from Certain Drugs”

https://pubmed.ncbi.nlm.nih.gov/38114467

This study characterized germline-somatic mutation interactions in breast cancer in a large Chinese cohort, finding that two-hit inactivation of DNA repair genes is associated with greater clinical benefits from certain drugs and increased genome instability.