“Comparing Separable and Inseparable Silk Fibroin Microneedles for Colchicine Transdermal Delivery: In Vivo Anti-Gout Effects and Mechanical Strength”

https://pubmed.ncbi.nlm.nih.gov/38114734

This study developed and compared separable and inseparable silk fibroin microneedles for transdermal delivery of colchicine, demonstrating that separable microneedles have greater mechanical strength, insertion ability, and in vivo anti-gout effects, offering a promising route for colchicine delivery.