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https://pubmed.ncbi.nlm.nih.gov/38115208
This phase I study found that combining pembrolizumab (PD-1 inhibitor) with either itacitinib (JAK1 inhibitor) or parsaclisib (PI3Kδ inhibitor) in patients with advanced solid tumors showed limited clinical activity and little effect on T-cell infiltration in the tumor, and thus does not support continued development of these combinations.