“A Rose Model and Thermodynamic Perturbation Theory Predict Hydrophobic Effects of Nonpolar Solutes”

https://pubmed.ncbi.nlm.nih.gov/38115497

This study uses a simple “rose model” of water and thermodynamic perturbation theory to accurately predict the hydrophobic effect of nonpolar solutes at higher temperatures and qualitative trends at low temperatures, offering a computationally efficient alternative to computer simulations.