“Genotoxic, Mutagenic, and Hepatotoxic Effects of Thermogenic Pre-Workout Supplements Containing 1,3-Dimethylamylamine and Caffeine: A Warning for the Dietary Supplement Industry”

https://pubmed.ncbi.nlm.nih.gov/38115604

The abstract reports that two popular thermogenic pre-workout supplements containing 1,3-dimethylamylamine and caffeine were found to be genotoxic, mutagenic, and hepatotoxic in various in vitro assays, and to cause oxidative stress, but the individual compounds tested in silico did not show these effects, highlighting the need for proper safety measures and surveillance in the dietary supplement industry.