“Transcription Factor 12 as a Novel Cofactor in IGH::DUX4 Transcriptional Complexes: A Potential Drug Target for B-Cell Acute Lymphoblastic Leukaemia”

https://pubmed.ncbi.nlm.nih.gov/38115701

The study identifies transcription factor 12 (TCF12) as a novel cofactor in IGH::DUX4 transcriptional complexes that mediates a positive self-feedback regulatory mechanism in IGH::DUX4-driven oncogenic transaction, suggesting a potential drug target for B-cell acute lymphoblastic leukaemia.