“Rare Variants and Polygenic Inheritance in Turkish Families with Recurrent Multiple Myeloma”

https://pubmed.ncbi.nlm.nih.gov/38115798

This study identified rare disease-causing variants in various genes, including some previously linked to familial multiple myeloma, in Turkish families with recurrent multiple myeloma cases, suggesting a polygenic inheritance pattern and the potential involvement of ubiquitination, V(D)J recombination, and the PI3K/AKT/mTOR pathway in the disease’s pathogenesis.