“Integration of ζ-Deficient CARs into CD3-zeta Gene Enhances Cytotoxicity in T and NK Cells for Allogeneic Cell Therapies”

https://pubmed.ncbi.nlm.nih.gov/38116030

The integration of ζ-deficient CARs into the CD3-zeta gene has been shown to convey potent cytotoxicity in T and NK cells, enabling the development of allogeneic off-the-shelf cell therapies using redirected killer lymphocytes.