“Novel Hydroxylamine Bioisostere Enhances Drug Efflux and hERG Affinity in Dual Kinase Inhibitor, with Reduced Basicity and without Mutagenicity Concerns”

https://pubmed.ncbi.nlm.nih.gov/38116407

A novel hydroxylamine bioisostere enhances drug efflux and hERG affinity in a dual kinase inhibitor, with reduced basicity and without typical mutagenicity concerns.