“6-Methyl Modification on Antifolate Drugs Abolishes Transport by RFC but Preserves Efficacy and Selectivity for Tumor-Selective Transporters”

https://pubmed.ncbi.nlm.nih.gov/38116433

A 6-methyl modification on certain antifolate drugs, like pemetrexed, abolishes transport by the ubiquitous RFC while preserving antitumor efficacy and selectivity for tumor-selective transporters, suggesting a promising approach for tumor-targeted therapeutics.