“Filamin-C Truncating Variants Can Cause Severe Left-Sided Arrhythmogenic Cardiomyopathy”

https://pubmed.ncbi.nlm.nih.gov/38116480

The abstract reports a case series of patients with filamin-C truncating variants attending a specialized cardiac genetic clinic, finding that these variants can cause a left-sided arrhythmogenic cardiomyopathy phenotype with a high risk of severe cardiac outcomes including end-stage heart failure and sudden cardiac death.