“Gene Expression Analysis Identifies Genetic Switches Driving Cigarette-Smoke Induced Inflammation to Cancer or Emphysema”

https://pubmed.ncbi.nlm.nih.gov/38116482

This study utilized gene expression analysis in former smokers to identify genetic switches between cigarette-smoke induced inflammation leading to cancer or emphysema, finding that cancer progression is associated with increased and stickier neutrophils, while emphysema is associated with stickier and longer-living macrophages, and two genes, ANXA2 and HIV1-rev, may play a pivotal role in disease outcome.