“Assessing Cardiac Myofilament Calcium Sensitivity: Current Methods, Limitations, and Proposed New Approach”

https://pubmed.ncbi.nlm.nih.gov/38116581

This review discusses current methods for assessing cardiac myofilament calcium sensitivity, highlights their limitations in studying dynamic changes, and proposes the need for a new method involving simultaneous measurements of cytosolic calcium and troponin C activation in actively contracting muscle with a biophysical model for interpretation.