“Thermodynamic Approach for Analyzing Relative Permittivity and Solvent Mole Fraction in S(N)1 Reactions: A Study of Tert-Butyl Chloride Hydrolysis Rates”

https://pubmed.ncbi.nlm.nih.gov/38116641

This study presents a thermodynamic approach to analyze the relative permittivity and solvent mole fraction models for S(N)1 reactions, and demonstrates its applications through examining the hydrolysis rates of tert-butyl chloride in an acetonitrile/water solvent system under different conditions, to distinguish and quantify bulk electrostatic effects and close-range solute-solvent interactions.