“Infusion Reactions to Adeno-Associated Virus Gene Therapy: Current Challenges and Future Research”

https://pubmed.ncbi.nlm.nih.gov/38116715

Infusion reactions to adeno-associated virus (AAV) gene therapy, caused by Toll-like receptor activation and pro-inflammatory cytokines, present a significant challenge to the safety and efficacy of AAV-based gene therapy, with current treatment options being inadequate and in need of further research.