“Lower Yields in Phosphoramidite Synthesis of Certain DNA Sequences: A Study of Depurination and Dinucleotide Combinations”

https://pubmed.ncbi.nlm.nih.gov/38116988

The study found that certain sequences with repeated deoxyadenosine residues and specific dinucleotide steps resulted in lower yields in solid-phase synthesis using phosphoramidite chemistry, likely due to depurination during detritylation and intrinsic challenges of specific dinucleotide combinations.