“BCL-2 Attenuates Lung Fibrosis by Regulating Endoplasmic Reticulum Stress and Extracellular Matrix Accumulation”

https://pubmed.ncbi.nlm.nih.gov/38117250

The study suggests that in lungs, BCL-2 attenuates endoplasmic reticulum stress and limits extracellular matrix accumulation, and its inhibition leads to enhanced fibrosis due to the RNAase activity of IRE1a downregulating MRC2 mRNA and protein.