“Methionine Oxidation Impact on IgG1 mAb Higher Order Structure: Sensitivity and Reliability of NMR and Chemometric Analysis in Biopharmaceutical Characterization”

https://pubmed.ncbi.nlm.nih.gov/38117548

This study uses various analytical methods, including NMR and chemometric analysis, to comprehensively characterize the impact of methionine oxidation on the higher order structure of an IgG1 mAb, demonstrating the sensitivity and reliability of these methods in biopharmaceutical characterization.