“A KYNA-NMDA-α7nAChR-Centric Approach to Substance Use Disorders: Achieving Kynurenic Acid Homeostasis through Integrative Pathophysiology and Pharmacology” (Note: This is a concise version of the title in sentence case, as the original text is a title of an abstract and not a full paper.)

https://pubmed.ncbi.nlm.nih.gov/38117676

The abstract proposes a new “KYNA-NMDA-α7nAChR-centric” approach to treating substance use disorders by achieving kynurenic acid (KYNA) homeostasis through integrative pathophysiology and pharmacology, with a focus on the kynurenine pathway and investigational medications such as memantine, galantamine, and N-acetylcysteine.