“Discovery of Inhibitors for Antibiotic-Resistance Enzymes OXA-48 and NDM-1 Using DNA-Encoded Chemical Library”

https://pubmed.ncbi.nlm.nih.gov/38117688

A DNA-encoded chemical library was used to discover novel micromolar to nanomolar inhibitors of the β-lactamase enzymes OXA-48 and NDM-1, which cause resistance to last-resort antibiotics, by targeting the carboxylate-binding pocket.