“Ir/Zn-Cocatalyzed Atroposelective [2+2+2] Cycloaddition of 1,6-Diynes and Ynamines to Construct Functionalized C─N Axially Chiral Indoles and Pyrroles”

https://pubmed.ncbi.nlm.nih.gov/38117883

This study reports the development of an Ir/Zn-cocatalyzed atroposelective [2+2+2] cycloaddition of 1,6-diynes and ynamines to construct various functionalized C─N axially chiral indoles and pyrroles in high yields, chemoselectivities, and enantioselectivities, providing a more efficient and reliable alternative to previous methods for asymmetric alkyne [2+2+2] cyclotrimerization.