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https://pubmed.ncbi.nlm.nih.gov/38093148
This study developed a multiscale computational model for transforming growth factor beta-stimulated calcific aortic valve disease, finding that most myofibroblasts and osteoblast-like cells die due to lack of nutrients, contributing to calcium nodules and fibrosis, and suggesting that this modeling framework could aid in understanding the complexity of biological systems and developing novel therapeutic approaches for related diseases.