AI generated summary of Pubmed citation/abstract with PMID 38093483

https://pubmed.ncbi.nlm.nih.gov/38093483
The study developed a novel multifunctional probe, [68Ga]Ga-NOTA-Cy5-R1, for noninvasive detection of PD-L1 expression in cancer. PD-L1 is a critical target for cancer immunotherapy, and its expression varies among patients. The probe showed good specificity and sensitivity to PD-L1 in vitro and in vivo. It can sensitively and specifically bind to PD-L1 positive tumors, with rapid clearance from nontarget tissues and a high signal-to-noise ratio. Moreover, [68Ga]Ga-NOTA-Cy5-R1 PET imaging can monitor the dynamic changes of PD-L1 expression in tumors, allowing for personalized cancer immunotherapy. The study suggests that this dual-modality PET/NIRF imaging probe can help direct and promote the clinical practice of ICIs therapy.