“Succinate Accumulation Promotes Cardiac Fibrosis and Heart Aging: A Potential Target for Intervention”

https://pubmed.ncbi.nlm.nih.gov/38112098

The abstract reports a study’s findings that age-induced accumulation of the metabolite succinate promotes cardiac fibrosis by stimulating fibroblast activation and apoptosis resistance, suggesting that targeting succinate generation or its downstream effects may be a promising strategy for slowing heart aging.