“Pravastatin Use in Diabetes Patients May Promote Vascular Calcification via Bacteroides Fragilis Metabolite”

https://pubmed.ncbi.nlm.nih.gov/38112268

Pravastatin, a lipid-lowering drug commonly used in diabetes patients, may promote vascular calcification by activating gut bacterium Bacteroides fragilis to produce a metabolite, 3,4,5-trimethoxycinnamic acid, which induces macrophage M1 polarization.