“Four-Dimensional Imaging: A New Technique for Visualizing Protein Conformational Changes in Cryo-Electron Microscopy Experiments”

https://pubmed.ncbi.nlm.nih.gov/38112413

The abstract describes a new technique called “four-dimensional imaging” that uses molecular simulations and manifold learning to reconstruct and visualize protein conformational changes in cryo-electron microscopy experiments, without requiring three-dimensional electron density maps.