“No Significant Change in Venous Malformation or Klippel-Trenaunay Syndrome Lesion Volume After 6 Months: Implications for Clinical Trial Design”

https://pubmed.ncbi.nlm.nih.gov/38112724

This study of venous malformation and Klippel-Trenaunay Syndrome patients followed over 6 months found no significant change in lesion volume or other factors, suggesting that a Phase 2 clinical trial without a placebo arm could be scientifically justified.