Mycobacterium tuberculosis’ ParDE1 toxin-antitoxin system repurposed as gyrase inhibitor for potential TB drug development

https://pubmed.ncbi.nlm.nih.gov/38113275

Mycobacterium tuberculosis’ ParDE1 toxin-antitoxin system can be remodeled to release a toxin that inhibits gyrase, suggesting a potential new approach for developing TB drugs.