“Development and Validation of a Method to Simultaneously Determine Four Drugs in Rabbit Tear Fluid and Cornea, with PK-PD Evaluation for Treating Microbial Keratitis”

https://pubmed.ncbi.nlm.nih.gov/38113826

This study developed and validated a method to simultaneously determine four different drugs in rabbit tear fluid and cornea, and used pharmacokinetic-pharmacodynamic (PK-PD) evaluation to predict dosing frequency for treating microbial keratitis caused by Staphylococcus aureus and E. coli.