“Plasma Protein Binding Rates of Shuganning Injection Components: Significant Interspecies Differences and High Binding Rates in Rats and Humans”

https://pubmed.ncbi.nlm.nih.gov/38114225

This study determined the plasma protein binding rates of 10 components in Shuganning Injection, a traditional Chinese medicine, in both rat and human plasma using equilibrium dialysis and UPLC-MS/MS, finding significant interspecies differences and high binding rates for most components.