New T7SS Substrate TslA, Widely Found in Bacillota Phyla with Phospholipase A Activity and Immunity Lipoprotein TilA, Identified in Study

https://pubmed.ncbi.nlm.nih.gov/38114483

The study identifies a new type of T7SS substrate, TslA, with a reverse domain arrangement and shows that it is widely found across Bacillota, including Staphylococcus, Enterococcus, and Listeria, and has a phospholipase A activity that is neutralized by the immunity lipoprotein TilA.