“Hypertonicity-induced Adipocyte Dedifferentiation and TNF-α Mediated Wnt/β-catenin Signaling: A Trade-off between Dedifferentiation and Apoptosis”

https://pubmed.ncbi.nlm.nih.gov/38115136

Hypertonicity induces adipocyte dedifferentiation by stimulating mitochondrial EVs to enhance TNF-α mediated activation of Wnt/β-catenin signaling, but this also causes apoptosis which can be avoided by direct activation of Wnt/β-catenin signaling.