“4-Thiaproline Accelerates Folding of Proteins with Native Cis Prolines without Affecting Stability or Enzymatic Activities”

https://pubmed.ncbi.nlm.nih.gov/38115231

The study finds that the amino acid analogue 4-thiaproline can significantly accelerate the slow folding phase of proteins containing cis prolines in the native state, without affecting their thermodynamic stability or enzymatic activities.