“Triptolide Inhibits RORγt Activation and JAK2/STAT3 Signaling Pathway, Impacting T Helper 17 Cells Differentiation in Ankylosing Spondylitis: A Theoretical Basis for Tripterygium wilfordii Utilization”

https://pubmed.ncbi.nlm.nih.gov/38115356

Triptolide, an active ingredient in Tripterygium wilfordii, inhibits the activation of RORγt and the JAK2/STAT3 signaling pathway, and inhibits the differentiation of T helper 17 cells, providing a theoretical basis for further development and utilization of TWHF in ankylosing spondylitis management.