“Ubiquilin 2 Deposition in UBQLN2-Linked ALS/FTD Predominantly Occurs in Asymptomatic Central Nervous System Regions, with Symptoms Corresponding to TDP-43 Aggregation”

https://pubmed.ncbi.nlm.nih.gov/38115557

Ubiquilin 2 is mainly deposited in clinically unaffected regions throughout the CNS in UBQLN2-linked ALS/FTD, with symptomology mapping best to the aggregation of TDP-43.