“Discovery of 3H-Pyrido[1,2-c]pyrimidin-3-one Derivatives as Potential MAT2A Inhibitors for MTAP-Deleted Tumors Treatment”

https://pubmed.ncbi.nlm.nih.gov/38116423

A new series of 3H-pyrido[1,2-c]pyrimidin-3-one derivatives have been discovered as potential and orally bioavailable MAT2A inhibitors for the treatment of MTAP-deleted tumors, with compound 30 showing superior in vivo potency compared to the current clinical compound AG-270.