Home ยป Repurposing of Azole Antifungal Clotrimazole as Potential Treatment for Drug-Resistant Tuberculosis: A Comparative Study with Linezolid and MAO Enzymes

Repurposing of Azole Antifungal Clotrimazole as Potential Treatment for Drug-Resistant Tuberculosis: A Comparative Study with Linezolid and MAO Enzymes

by satcit

https://pubmed.ncbi.nlm.nih.gov/38116435

The abstract reports the repurposing of the azole antifungal Clotrimazole as a potential treatment for drug-resistant tuberculosis, showing equipotent activity against the Mtb H37Rv strain compared to Linezolid, but with significantly less inhibition of monoamine oxidase (MAO) enzymes, suggesting a reduced serotonergic toxicity burden.

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