“Novel Bacterial Topoisomerase Inhibitors with Potent Activity against Gram-Negative Bacteria but Limited Development due to Unusual Pharmacokinetic Profile”

https://pubmed.ncbi.nlm.nih.gov/38116438

Researchers have developed new NBTIs (Novel Bacterial Topoisomerase Inhibitors) with a indane DNA intercalating moiety that exhibit potent activity against Gram-negative bacteria and minimal hERG inhibition, although their unusual pharmacokinetic profile limits their development as potential new antibiotics.