“Design and Expression of SARS-CoV-2 Chimeric Spike Protein in E. coli as a Subunit Vaccine Candidate Inducing Immune Response and Neutralizing Antibodies against Omicron Variant”

https://pubmed.ncbi.nlm.nih.gov/38116554

This study describes the design and expression of a recombinant chimeric spike protein from SARS-CoV-2 in E. coli, which induces a strong immune response and produces neutralizing antibodies against various virus serotypes, including the omicron variant, suggesting its potential as a subunit vaccine candidate.