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https://pubmed.ncbi.nlm.nih.gov/38116641
This study presents a thermodynamic approach to analyze the relative permittivity and solvent mole fraction models for S(N)1 reactions, and demonstrates its applications through examining the hydrolysis rates of tert-butyl chloride in an acetonitrile/water solvent system under different conditions, to distinguish and quantify bulk electrostatic effects and close-range solute-solvent interactions.