“Ser38-His93-Asn91 Triad in HCV NS5A Y93H Variant Enables Dimer Formation and RNA Replication, Conferring Resistance to NS5A Inhibitors”

https://pubmed.ncbi.nlm.nih.gov/38116713

The Ser38-His93-Asn91 triad in the Y93H variant of HCV NS5A allows it to form a dimer and conduct RNA replication even in the absence of NS5A inhibitors, thereby conferring resistance to these inhibitors.